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Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex
Mammalian mRNA biogenesis is dependent on specific recognition of a hexanucleotide AAUAAA motif in the polyadenylation signals (PAS) of pre-mRNA transcripts by the cleavage and polyadenylation specificity factor (CPSF) complex. Here we report a 3.1 Å resolution cryo-electron microscopy structure of...
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| 發表在: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6900284/ https://ncbi.nlm.nih.gov/pubmed/29358758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-017-0020-6 |
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