Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

Mammalian mRNA biogenesis is dependent on specific recognition of a hexanucleotide AAUAAA motif in the polyadenylation signals (PAS) of pre-mRNA transcripts by the cleavage and polyadenylation specificity factor (CPSF) complex. Here we report a 3.1 Å resolution cryo-electron microscopy structure of...

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Detaylı Bibliyografya
Yayımlandı:Nat Struct Mol Biol
Asıl Yazarlar: Clerici, Marcello, Faini, Marco, Muckenfuss, Lena M., Aebersold, Ruedi, Jinek, Martin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900284/
https://ncbi.nlm.nih.gov/pubmed/29358758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-017-0020-6
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