Development of a selective CDK7 covalent inhibitor reveals predominant cell cycle phenotype

Cyclin-dependent kinase 7 (CDK7) regulates both cell cycle and transcription, but its precise role remains elusive. We previously described THZ1, a CDK7 inhibitor, which dramatically inhibits super-enhancer associated gene expression. However, potent CDK12/13 off-target activity obscured CDK7s contr...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell Chem Biol
मुख्य लेखकों: Olson, Calla M., Liang, Yanke, Leggett, Alan, Park, Woojun D., Li, Lianbo, Mills, Caitlin E., Elsarrag, Selma Z., Ficarro, Scott B., Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A., Sorger, Peter K., Westover, Ken D., Lin, Charles Y., Kwiatkowski, Nicholas, Gray, Nathanael S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588464/
https://ncbi.nlm.nih.gov/pubmed/30905681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.02.012
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