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ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain
Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been found to act also as a hydrotrope to maintain protein homeostasis. ATP bivalently binds the disordered domain of FUS containing the RG/RGG sequence motif and thereby affects FUS liquid-liquid phase separation....
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| 發表在: | Commun Biol |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6586847/ https://ncbi.nlm.nih.gov/pubmed/31240261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0463-x |
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