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ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues
Mysteriously neurons maintain ATP concentrations of ~3 mM but whether ATP modulates TDP-43 LLPS remains completely unexplored. Here we characterized the effect of ATP on LLPS of TDP-43 PLD and seven mutants by DIC and NMR. The results revealed: 1) ATP induces and subsequently dissolves LLPS of TDP-4...
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| Veröffentlicht in: | Commun Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8192790/ https://ncbi.nlm.nih.gov/pubmed/34112944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02247-2 |
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