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A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids

526-residue Fused in sarcoma (FUS) undergoes liquid–liquid phase separation (LLPS) for its functions, which can further transit into pathological aggregation. ATP and nucleic acids, the universal cellular actors, were shown to modulate LLPS of FUS in a unique manner: enhancement and then dissolution...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Kang, Jian, Lim, Liangzhong, Lu, Yimei, Song, Jianxing
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590835/
https://ncbi.nlm.nih.gov/pubmed/31188823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000327
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