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ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain

Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been found to act also as a hydrotrope to maintain protein homeostasis. ATP bivalently binds the disordered domain of FUS containing the RG/RGG sequence motif and thereby affects FUS liquid-liquid phase separation....

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Kang, Jian, Lim, Liangzhong, Song, Jianxing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586847/
https://ncbi.nlm.nih.gov/pubmed/31240261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0463-x
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