Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation

Activation of invariant natural killer T lymphocytes (iNKT cells) by α-galactosylceramide (α-GC) elicits a range of pro-inflammatory or anti-inflammatory immune responses. We report the synthesis and characterization of a series of α-GC analogues with acyl chains of varying length and a terminal ben...

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Publié dans:Bioconjug Chem
Auteurs principaux: Veerapen, Natacha, Kharkwal, Shalu Sharma, Jervis, Peter, Bhowruth, Veemal, Besra, Amareeta K., North, Simon J., Haslam, Stuart M., Dell, Anne, Hobrath, Judith, Quaid, Padraic J., Moynihan, Patrick J., Cox, Liam R., Kharkwal, Himanshu, Zauderer, Maurice, Besra, Gurdyal S., Porcelli, Steven A.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586470/
https://ncbi.nlm.nih.gov/pubmed/30085659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00484
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