Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T Cell Engagers Generates Anti-Tumor Immunity While Avoiding Anergy

CD1d-restricted invariant natural killer T cells (iNKT cells) mediate strong anti-tumor immunity when stimulated by glycolipid agonists. However, attempts to develop effective iNKT cell agonists for clinical applications have been thwarted by potential problems with dose-limiting toxicity and by act...

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Publicado en:Cancer Res
Main Authors: Kharkwal, Shalu Sharma, Johndrow, Christopher T., Veerapen, Natacha, Kharkwal, Himanshu, Saavedra-Avila, Noemi A., Carreño, Leandro J., Rothberg, Samantha, Zhang, Jinghang, Garforth, Scott J., Jervis, Peter J., Zhang, Lianjun, Donda, Alena, Besra, Amareeta K., Cox, Liam R., Almo, Steven C., Howell, Alan, Evans, Elizabeth E., Zauderer, Maurice, Besra, Gurdyal S., Porcelli, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137529/
https://ncbi.nlm.nih.gov/pubmed/33483371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2219
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