Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T Cell Engagers Generates Anti-Tumor Immunity While Avoiding Anergy

CD1d-restricted invariant natural killer T cells (iNKT cells) mediate strong anti-tumor immunity when stimulated by glycolipid agonists. However, attempts to develop effective iNKT cell agonists for clinical applications have been thwarted by potential problems with dose-limiting toxicity and by act...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Kharkwal, Shalu Sharma, Johndrow, Christopher T., Veerapen, Natacha, Kharkwal, Himanshu, Saavedra-Avila, Noemi A., Carreño, Leandro J., Rothberg, Samantha, Zhang, Jinghang, Garforth, Scott J., Jervis, Peter J., Zhang, Lianjun, Donda, Alena, Besra, Amareeta K., Cox, Liam R., Almo, Steven C., Howell, Alan, Evans, Elizabeth E., Zauderer, Maurice, Besra, Gurdyal S., Porcelli, Steven A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137529/
https://ncbi.nlm.nih.gov/pubmed/33483371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2219
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