Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T Cell Engagers Generates Anti-Tumor Immunity While Avoiding Anergy

CD1d-restricted invariant natural killer T cells (iNKT cells) mediate strong anti-tumor immunity when stimulated by glycolipid agonists. However, attempts to develop effective iNKT cell agonists for clinical applications have been thwarted by potential problems with dose-limiting toxicity and by act...

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Pubblicato in:Cancer Res
Autori principali: Kharkwal, Shalu Sharma, Johndrow, Christopher T., Veerapen, Natacha, Kharkwal, Himanshu, Saavedra-Avila, Noemi A., Carreño, Leandro J., Rothberg, Samantha, Zhang, Jinghang, Garforth, Scott J., Jervis, Peter J., Zhang, Lianjun, Donda, Alena, Besra, Amareeta K., Cox, Liam R., Almo, Steven C., Howell, Alan, Evans, Elizabeth E., Zauderer, Maurice, Besra, Gurdyal S., Porcelli, Steven A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137529/
https://ncbi.nlm.nih.gov/pubmed/33483371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2219
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