Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation

Activation of invariant natural killer T lymphocytes (iNKT cells) by α-galactosylceramide (α-GC) elicits a range of pro-inflammatory or anti-inflammatory immune responses. We report the synthesis and characterization of a series of α-GC analogues with acyl chains of varying length and a terminal ben...

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Publicat a:Bioconjug Chem
Autors principals: Veerapen, Natacha, Kharkwal, Shalu Sharma, Jervis, Peter, Bhowruth, Veemal, Besra, Amareeta K., North, Simon J., Haslam, Stuart M., Dell, Anne, Hobrath, Judith, Quaid, Padraic J., Moynihan, Patrick J., Cox, Liam R., Kharkwal, Himanshu, Zauderer, Maurice, Besra, Gurdyal S., Porcelli, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586470/
https://ncbi.nlm.nih.gov/pubmed/30085659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.8b00484
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