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Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636

The identification of potential new anti-tubercular chemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB). Libraries of NAS-21 and NAS-91 analogues were synthesized and evaluated for their whole-cell activity against M...

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Autors principals: Bhowruth, Veemal, Brown, Alistair K., Besra, Gurdyal S.
Format: Artigo
Idioma:Inglês
Publicat: Microbiology Society 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885650/
https://ncbi.nlm.nih.gov/pubmed/18599816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/mic.0.2008/017434-0
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