Cicero predicts cis-regulatory DNA interactions from single cell chromatin accessibility data

Linking regulatory DNA elements to their target genes, which may be located hundreds of kilobases away, remains challenging. Here we introduce Cicero, an algorithm that identifies coaccessible pairs of DNA elements using single-cell chromatin accessibility data, and so connects regulatory elements t...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Pliner, Hannah A., Packer, Jonathan, McFaline-Figueroa, José L., Cusanovich, Darren A., Daza, Riza, Aghamirzaie, Delasa, Srivatsan, Sanjay, Qiu, Xiaojie, Jackson, Dana, Minkina, Anna, Adey, Andrew, Steemers, Frank J., Shendure, Jay, Trapnell, Cole
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582963/
https://ncbi.nlm.nih.gov/pubmed/30078726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.044
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