Joint profiling of chromatin accessibility and gene expression in thousands of single cells

Although we can increasingly measure transcription, chromatin, methylation, etc. at single cell resolution, most assays survey only one aspect of cellular biology. Here we describe sci-CAR, a combinatorial indexing-based co-assay that jointly profiles chromatin accessibility and mRNA in each of thou...

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Pubblicato in:Science
Autori principali: Cao, Junyue, Cusanovich, Darren A., Ramani, Vijay, Aghamirzaie, Delasa, Pliner, Hannah A., Hill, Andrew J., Daza, Riza M., McFaline-Figueroa, Jose L., Packer, Jonathan S., Christiansen, Lena, Steemers, Frank J., Adey, Andrew C., Trapnell, Cole, Shendure, Jay
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571013/
https://ncbi.nlm.nih.gov/pubmed/30166440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau0730
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