Joint profiling of chromatin accessibility and gene expression in thousands of single cells

Although we can increasingly measure transcription, chromatin, methylation, etc. at single cell resolution, most assays survey only one aspect of cellular biology. Here we describe sci-CAR, a combinatorial indexing-based co-assay that jointly profiles chromatin accessibility and mRNA in each of thou...

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Udgivet i:Science
Main Authors: Cao, Junyue, Cusanovich, Darren A., Ramani, Vijay, Aghamirzaie, Delasa, Pliner, Hannah A., Hill, Andrew J., Daza, Riza M., McFaline-Figueroa, Jose L., Packer, Jonathan S., Christiansen, Lena, Steemers, Frank J., Adey, Andrew C., Trapnell, Cole, Shendure, Jay
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6571013/
https://ncbi.nlm.nih.gov/pubmed/30166440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau0730
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