Massively multiplex chemical transcriptomics at single-cell resolution

High-throughput chemical screens typically use coarse assays such as cell survival, limiting what can be learned about mechanisms of action, off-target effects, and heterogeneous responses. Here, we introduce “sci-Plex,” which uses “nuclear hashing” to quantify global transcriptional responses to th...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Srivatsan, Sanjay R., McFaline-Figueroa, José L., Ramani, Vijay, Saunders, Lauren, Cao, Junyue, Packer, Jonathan, Pliner, Hannah A., Jackson, Dana L., Daza, Riza M., Christiansen, Lena, Zhang, Fan, Steemers, Frank, Shendure, Jay, Trapnell, Cole
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289078/
https://ncbi.nlm.nih.gov/pubmed/31806696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax6234
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