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Massively multiplex chemical transcriptomics at single-cell resolution
High-throughput chemical screens typically use coarse assays such as cell survival, limiting what can be learned about mechanisms of action, off-target effects, and heterogeneous responses. Here, we introduce “sci-Plex,” which uses “nuclear hashing” to quantify global transcriptional responses to th...
שמור ב:
| הוצא לאור ב: | Science |
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| Main Authors: | , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7289078/ https://ncbi.nlm.nih.gov/pubmed/31806696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax6234 |
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