Cicero predicts cis-regulatory DNA interactions from single cell chromatin accessibility data

Linking regulatory DNA elements to their target genes, which may be located hundreds of kilobases away, remains challenging. Here we introduce Cicero, an algorithm that identifies coaccessible pairs of DNA elements using single-cell chromatin accessibility data, and so connects regulatory elements t...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Pliner, Hannah A., Packer, Jonathan, McFaline-Figueroa, José L., Cusanovich, Darren A., Daza, Riza, Aghamirzaie, Delasa, Srivatsan, Sanjay, Qiu, Xiaojie, Jackson, Dana, Minkina, Anna, Adey, Andrew, Steemers, Frank J., Shendure, Jay, Trapnell, Cole
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582963/
https://ncbi.nlm.nih.gov/pubmed/30078726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.044
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