Cicero predicts cis-regulatory DNA interactions from single cell chromatin accessibility data

Linking regulatory DNA elements to their target genes, which may be located hundreds of kilobases away, remains challenging. Here we introduce Cicero, an algorithm that identifies coaccessible pairs of DNA elements using single-cell chromatin accessibility data, and so connects regulatory elements t...

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Publicat a:Mol Cell
Autors principals: Pliner, Hannah A., Packer, Jonathan, McFaline-Figueroa, José L., Cusanovich, Darren A., Daza, Riza, Aghamirzaie, Delasa, Srivatsan, Sanjay, Qiu, Xiaojie, Jackson, Dana, Minkina, Anna, Adey, Andrew, Steemers, Frank J., Shendure, Jay, Trapnell, Cole
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582963/
https://ncbi.nlm.nih.gov/pubmed/30078726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.044
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