Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39

In the yeast U1 snRNP the Prp39/Prp42 heterodimer is essential for early steps of spliceosome assembly. In metazoans no Prp42 ortholog exists, raising the question how the heterodimer is functionally substituted. Here we present the crystal structure of murine PRPF39, which forms a homodimer. Struct...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: De Bortoli, Francesca, Neumann, Alexander, Kotte, Ana, Timmermann, Bernd, Schüler, Thomas, Wahl, Markus C, Loll, Bernhard, Heyd, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582350/
https://ncbi.nlm.nih.gov/pubmed/30949712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz243
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados