Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39

In the yeast U1 snRNP the Prp39/Prp42 heterodimer is essential for early steps of spliceosome assembly. In metazoans no Prp42 ortholog exists, raising the question how the heterodimer is functionally substituted. Here we present the crystal structure of murine PRPF39, which forms a homodimer. Struct...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: De Bortoli, Francesca, Neumann, Alexander, Kotte, Ana, Timmermann, Bernd, Schüler, Thomas, Wahl, Markus C, Loll, Bernhard, Heyd, Florian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
RNA and RNA-protein complexes
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582350/
https://ncbi.nlm.nih.gov/pubmed/30949712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz243
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