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Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39
In the yeast U1 snRNP the Prp39/Prp42 heterodimer is essential for early steps of spliceosome assembly. In metazoans no Prp42 ortholog exists, raising the question how the heterodimer is functionally substituted. Here we present the crystal structure of murine PRPF39, which forms a homodimer. Struct...
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| Yayımlandı: | Nucleic Acids Res |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6582350/ https://ncbi.nlm.nih.gov/pubmed/30949712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz243 |
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