Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation

T cells are nodal players in the adaptive immune response against pathogens and malignant cells. Alternative splicing plays a crucial role in T cell activation, which is analyzed mainly at later time points upon stimulation. Here we have discovered a 2-h time window early after stimulation where opt...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Bose, Debojit, Neumann, Alexander, Timmermann, Bernd, Meinke, Stefan, Heyd, Florian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6664609/
https://ncbi.nlm.nih.gov/pubmed/31160491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00035-19
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