Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether NPC quality control is compromised in aging mitotic cells. Our images of single yeast cells during aging, show that...

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Udgivet i:eLife
Main Authors: Rempel, Irina L, Crane, Matthew M, Thaller, David J, Mishra, Ankur, Jansen, Daniel PM, Janssens, Georges, Popken, Petra, Akşit, Arman, Kaeberlein, Matt, van der Giessen, Erik, Steen, Anton, Onck, Patrick R, Lusk, C Patrick, Veenhoff, Liesbeth M
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579512/
https://ncbi.nlm.nih.gov/pubmed/31157618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48186
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