Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether NPC quality control is compromised in aging mitotic cells. Our images of single yeast cells during aging, show that...

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Veröffentlicht in:eLife
Hauptverfasser: Rempel, Irina L, Crane, Matthew M, Thaller, David J, Mishra, Ankur, Jansen, Daniel PM, Janssens, Georges, Popken, Petra, Akşit, Arman, Kaeberlein, Matt, van der Giessen, Erik, Steen, Anton, Onck, Patrick R, Lusk, C Patrick, Veenhoff, Liesbeth M
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6579512/
https://ncbi.nlm.nih.gov/pubmed/31157618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48186
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