Conformational plasticity of the intracellular cavity of GPCR−G-protein complexes leads to G-protein promiscuity and selectivity

While the dynamics of the intracellular surface in agonist-stimulated GPCRs is well studied, the impact of GPCR dynamics on G-protein selectivity remains unclear. Here, we combine molecular dynamics simulations with live-cell FRET and secondary messenger measurements, for 21 GPCR−G-protein combinati...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Sandhu, Manbir, Touma, Anja M., Dysthe, Matthew, Sadler, Fredrik, Sivaramakrishnan, Sivaraj, Vaidehi, Nagarajan
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2019
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575595/
https://ncbi.nlm.nih.gov/pubmed/31138704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820944116
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