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Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in ‘Ene’-Reductases
Flavin-dependent ‘ene’-reductases (EREDs) are known to stereoselectively reduce activated alkenes, but are inactive toward carbonyls. Herein we demonstrate that in the presence of photoredox catalysts, these enzymes will reduce aromatic ketones. Mechanistic experiments suggest this reaction proceeds...
Tallennettuna:
| Julkaisussa: | Angew Chem Int Ed Engl |
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| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6570536/ https://ncbi.nlm.nih.gov/pubmed/30951226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201902005 |
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