A Photoswitchable Agonist for the Histamine H(3) Receptor, a Prototypic Family A G‐Protein‐Coupled Receptor

Spatiotemporal control over biochemical signaling processes involving G protein‐coupled receptors (GPCRs) is highly desired for dissecting their complex intracellular signaling. We developed sixteen photoswitchable ligands for the human histamine H(3) receptor (hH(3)R). Upon illumination, key compou...

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Udgivet i:Angew Chem Int Ed Engl
Main Authors: Hauwert, Niels J., Mocking, Tamara A. M., Da Costa Pereira, Daniel, Lion, Ken, Huppelschoten, Yara, Vischer, Henry F., De Esch, Iwan J. P., Wijtmans, Maikel, Leurs, Rob
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563694/
https://ncbi.nlm.nih.gov/pubmed/30735597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201813110
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