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Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
The von Hippel-Lindau (VHL) and cereblon (CRBN) proteins are substrate recognition subunits of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL and CRBN are also the two most popular E3 ligases being recruited by bifunctional Proteolysis-targeting...
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| Publié dans: | Bioorg Med Chem |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier Science
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561380/ https://ncbi.nlm.nih.gov/pubmed/30826187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.048 |
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