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Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
The von Hippel-Lindau (VHL) and cereblon (CRBN) proteins are substrate recognition subunits of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL and CRBN are also the two most popular E3 ligases being recruited by bifunctional Proteolysis-targeting...
Shranjeno v:
| izdano v: | Bioorg Med Chem |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier Science
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6561380/ https://ncbi.nlm.nih.gov/pubmed/30826187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.048 |
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