Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

[Image: see text] Proteolysis targeting chimeras (PROTACs) are catalytic heterobifunctional molecules that can selectively degrade a protein of interest by recruiting a ubiquitin E3 ligase to the target, leading to its ubiquitylation and degradation by the proteasome. Most degraders lie outside the...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Klein, Victoria G., Townsend, Chad E., Testa, Andrea, Zengerle, Michael, Maniaci, Chiara, Hughes, Scott J., Chan, Kwok-Ho, Ciulli, Alessio, Lokey, R. Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2020
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488288/
https://ncbi.nlm.nih.gov/pubmed/32939229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00265
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