Symbiotic macrophage-glioma cell interactions reveal synthetic lethality in PTEN null glioma

Heterotypic interactions across diverse cell types can enable tumor progression and hold the potential to expand therapeutic interventions. Here, combined profiling and functional studies of glioma cells in glioblastoma multiforme (GBM) models establish that PTEN deficiency activates YAP1, which dir...

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Publicado en:Cancer Cell
Autores principales: Chen, Peiwen, Zhao, Di, Li, Jun, Liang, Xin, Li, Jiexi, Chang, Andrew, Henry, Verlene K., Lan, Zhengdao, Spring, Denise J., Rao, Ganesh, Wang, Y. Alan, DePinho, Ronald A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561349/
https://ncbi.nlm.nih.gov/pubmed/31185211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.003
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