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Synthetic lethal approaches to target cancers with loss of PTEN function
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP(3)) into phosphatidylinositol 4,5-bisphosphate (PIP(2)). The function of PTEN is regulated by different...
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| Publicado no: | Genes Dis |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Chongqing Medical University
2023
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614861/ https://ncbi.nlm.nih.gov/pubmed/37533462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2022.12.015 |
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