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Synthetic lethal approaches to target cancers with loss of PTEN function
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP(3)) into phosphatidylinositol 4,5-bisphosphate (PIP(2)). The function of PTEN is regulated by different...
Tallennettuna:
| Julkaisussa: | Genes Dis |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Chongqing Medical University
2023
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614861/ https://ncbi.nlm.nih.gov/pubmed/37533462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2022.12.015 |
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