Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN deficient cancer

Synthetic and collateral lethality have provided conceptual frameworks to identify cancer-specific vulnerabilities(1–3). Here, we explored an approach to identify potential synthetic lethal interactions through screening mutually exclusive deletion patterns in cancer genomes. We sought to identify ‘...

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Dettagli Bibliografici
Pubblicato in:Nature
Autori principali: Zhao, Di, Lu, Xin, Wang, Guocan, Lan, Zhengdao, Liao, Wenting, Li, Jun, Liang, Xin, Chen, Jasper Robin, Shah, Sagar, Shang, Xiaoying, Tang, Ming, Deng, Pingna, Dey, Prasenjit, Chakravarti, Deepavali, Chen, Peiwen, Spring, Denise J., Navone, Nora M., Troncoso, Patricia, Zhang, Jianhua, Wang, Y. Alan, DePinho, Ronald A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448706/
https://ncbi.nlm.nih.gov/pubmed/28166537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21357
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