Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN deficient cancer

Synthetic and collateral lethality have provided conceptual frameworks to identify cancer-specific vulnerabilities(1–3). Here, we explored an approach to identify potential synthetic lethal interactions through screening mutually exclusive deletion patterns in cancer genomes. We sought to identify ‘...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nature
Main Authors: Zhao, Di, Lu, Xin, Wang, Guocan, Lan, Zhengdao, Liao, Wenting, Li, Jun, Liang, Xin, Chen, Jasper Robin, Shah, Sagar, Shang, Xiaoying, Tang, Ming, Deng, Pingna, Dey, Prasenjit, Chakravarti, Deepavali, Chen, Peiwen, Spring, Denise J., Navone, Nora M., Troncoso, Patricia, Zhang, Jianhua, Wang, Y. Alan, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448706/
https://ncbi.nlm.nih.gov/pubmed/28166537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21357
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados