Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN deficient cancer

Synthetic and collateral lethality have provided conceptual frameworks to identify cancer-specific vulnerabilities(1–3). Here, we explored an approach to identify potential synthetic lethal interactions through screening mutually exclusive deletion patterns in cancer genomes. We sought to identify ‘...

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Vydáno v:Nature
Hlavní autoři: Zhao, Di, Lu, Xin, Wang, Guocan, Lan, Zhengdao, Liao, Wenting, Li, Jun, Liang, Xin, Chen, Jasper Robin, Shah, Sagar, Shang, Xiaoying, Tang, Ming, Deng, Pingna, Dey, Prasenjit, Chakravarti, Deepavali, Chen, Peiwen, Spring, Denise J., Navone, Nora M., Troncoso, Patricia, Zhang, Jianhua, Wang, Y. Alan, DePinho, Ronald A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448706/
https://ncbi.nlm.nih.gov/pubmed/28166537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21357
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