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Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN deficient cancer
Synthetic and collateral lethality have provided conceptual frameworks to identify cancer-specific vulnerabilities(1–3). Here, we explored an approach to identify potential synthetic lethal interactions through screening mutually exclusive deletion patterns in cancer genomes. We sought to identify ‘...
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| 發表在: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5448706/ https://ncbi.nlm.nih.gov/pubmed/28166537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21357 |
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