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Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN deficient cancer
Synthetic and collateral lethality have provided conceptual frameworks to identify cancer-specific vulnerabilities(1–3). Here, we explored an approach to identify potential synthetic lethal interactions through screening mutually exclusive deletion patterns in cancer genomes. We sought to identify ‘...
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| Vydáno v: | Nature |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5448706/ https://ncbi.nlm.nih.gov/pubmed/28166537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21357 |
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