Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN deficient cancer

Synthetic and collateral lethality have provided conceptual frameworks to identify cancer-specific vulnerabilities(1–3). Here, we explored an approach to identify potential synthetic lethal interactions through screening mutually exclusive deletion patterns in cancer genomes. We sought to identify ‘...

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Bibliografiske detaljer
Udgivet i:	Nature
Main Authors:	Zhao, Di, Lu, Xin, Wang, Guocan, Lan, Zhengdao, Liao, Wenting, Li, Jun, Liang, Xin, Chen, Jasper Robin, Shah, Sagar, Shang, Xiaoying, Tang, Ming, Deng, Pingna, Dey, Prasenjit, Chakravarti, Deepavali, Chen, Peiwen, Spring, Denise J., Navone, Nora M., Troncoso, Patricia, Zhang, Jianhua, Wang, Y. Alan, DePinho, Ronald A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2017
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5448706/ https://ncbi.nlm.nih.gov/pubmed/28166537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21357
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Synthetic essentiality of chromatin remodeling factor CHD1 in PTEN deficient cancer

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