Chromatin Regulator, CHD1, Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer

Genetic inactivation of PTEN is common in prostate cancer and correlates with poorer prognosis. We previously identified chromodomain-helicase-DNA-binding protein 1 (CHD1) as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive in vivo genetic evidence for, and mechanistic un...

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Publicado no:Cancer Discov
Main Authors: Zhao, Di, Cai, Li, Lu, Xin, Liang, Xin, Li, Jiexi, Chen, Peiwen, Ittmann, Michael, Shang, Xiaoying, Jiang, Shan, Li, Haoyan, Meng, Chenling, Flores, Ivonne, Song, Jian H., Horner, James W, Lan, Zhengdao, Wu, Chang-Jiun, Li, Jun, Chang, Qing, Chen, Ko-Chien, Wang, Guocan, Deng, Pingna, Spring, Denise J., Wang, Y. Alan, DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483306/
https://ncbi.nlm.nih.gov/pubmed/32385075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1352
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