Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization

The transformation of molecular binding events into cellular decisions is the basis of most biological signal transduction. A fundamental challenge faced by these systems is that reliance on protein–ligand chemical affinities alone generally results in poor sensitivity to ligand concentration, endan...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Chung, Jean K., Nocka, Laura M., Decker, Aubrianna, Wang, Qi, Kadlecek, Theresa A., Weiss, Arthur, Kuriyan, John, Groves, Jay T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561188/
https://ncbi.nlm.nih.gov/pubmed/31076553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819309116
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