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Structural mechanism for Bruton’s tyrosine kinase activation at the cell membrane
Bruton’s tyrosine kinase (Btk) is critical for B cell proliferation and activation, and the development of Btk inhibitors is a vigorously pursued strategy for the treatment of various B cell malignancies. A detailed mechanistic understanding of Btk activation has, however, been lacking. Here, inspir...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6511029/ https://ncbi.nlm.nih.gov/pubmed/31019091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819301116 |
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