Hatchet ribozyme structure and implications for cleavage mechanism

Small self-cleaving ribozymes catalyze site-specific cleavage of their own phosphodiester backbone with implications for viral genome replication, pre-mRNA processing, and alternative splicing. We report on the 2.1-Å crystal structure of the hatchet ribozyme product, which adopts a compact pseudosym...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zheng, Luqian, Falschlunger, Christoph, Huang, Kaiyi, Mairhofer, Elisabeth, Yuan, Shuguang, Wang, Juncheng, Patel, Dinshaw J., Micura, Ronald, Ren, Aiming
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6561176/
https://ncbi.nlm.nih.gov/pubmed/31088965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902413116
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