Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme

Here we report on the crystal structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme. Notably, 11 conserved spatially separated loop nucleotides are brought into close proximity at the ribozyme core through long-range interactions mediated by hydrated Mg(2+) cat...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Zheng, Luqian, Mairhofer, Elisabeth, Teplova, Marianna, Zhang, Ye, Ma, Jinbiao, Patel, Dinshaw J., Micura, Ronald, Ren, Aiming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660989/
https://ncbi.nlm.nih.gov/pubmed/29081514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01276-y
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