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Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate

The twister RNA is a recently discovered nucleolytic ribozyme that is present in both bacteria and eukarya. While its biological role remains unclear, crystal structure analyses and biochemical approaches have revealed critical features of its catalytic mechanism. Here, we set out to explore dynamic...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Vušurović, Nikola, Altman, Roger B., Terry, Daniel S., Micura, Ronald, Blanchard, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697751/
https://ncbi.nlm.nih.gov/pubmed/28598157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01549
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