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Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate

The twister RNA is a recently discovered nucleolytic ribozyme that is present in both bacteria and eukarya. While its biological role remains unclear, crystal structure analyses and biochemical approaches have revealed critical features of its catalytic mechanism. Here, we set out to explore dynamic...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Vušurović, Nikola, Altman, Roger B., Terry, Daniel S., Micura, Ronald, Blanchard, Scott C.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697751/
https://ncbi.nlm.nih.gov/pubmed/28598157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01549
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