A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class

Nucleolytic ribozymes catalyze site-specific cleavage of their phosphodiester backbones. A minimal version of the twister ribozyme is reported that lacks the phylogenetically conserved stem P1 while retaining wild-type activity. Atomic mutagenesis revealed that nitrogen atoms N1 and N3 of the adenin...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Košutić, Marija, Neuner, Sandro, Ren, Aiming, Flür, Sara, Wunderlich, Christoph, Mairhofer, Elisabeth, Vušurović, Nikola, Seikowski, Jan, Breuker, Kathrin, Höbartner, Claudia, Patel, Dinshaw J., Kreutz, Christoph, Micura, Ronald
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4715771/
https://ncbi.nlm.nih.gov/pubmed/26473980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201506601
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