Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course

BACKGROUND: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS. METHODS: Fifty-four therapy-naive Relapsing Remi...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Castro, Kamilah, Ntranos, Achilles, Amatruda, Mario, Petracca, Maria, Kosa, Peter, Chen, Emily Y., Morstein, Johannes, Trauner, Dirk, Watson, Corey T., Kiebish, Michael A., Bielekova, Bibiana, Inglese, Matilde, Katz Sand, Ilana, Casaccia, Patrizia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
Soggetti:
Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557766/
https://ncbi.nlm.nih.gov/pubmed/30981648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.087
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