Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course

BACKGROUND: Multiple Sclerosis (MS) results from genetic predisposition and environmental variables, including elevated Body Mass Index (BMI) in early life. This study addresses the effect of BMI on the epigenome of monocytes and disease course in MS. METHODS: Fifty-four therapy-naive Relapsing Remi...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Castro, Kamilah, Ntranos, Achilles, Amatruda, Mario, Petracca, Maria, Kosa, Peter, Chen, Emily Y., Morstein, Johannes, Trauner, Dirk, Watson, Corey T., Kiebish, Michael A., Bielekova, Bibiana, Inglese, Matilde, Katz Sand, Ilana, Casaccia, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557766/
https://ncbi.nlm.nih.gov/pubmed/30981648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.087
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