Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis

Cell-permeable formulations of metabolites, such as fumaric acid esters, have been used as highly effective immunomodulators in patients with multiple sclerosis and yet their mechanism of action remains elusive. Since fumaric acid esters are metabolites, and cell metabolism is highly intertwined wit...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Ntranos, Achilles, Ntranos, Vasilis, Bonnefil, Valentina, Liu, Jia, Kim-Schulze, Seunghee, He, Ye, Zhu, Yunjiao, Brandstadter, Rachel, Watson, Corey T, Sharp, Andrew J, Katz Sand, Ilana, Casaccia, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821213/
https://ncbi.nlm.nih.gov/pubmed/30698680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awy344
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