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Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains

Engineering of assembly line polyketide synthases (PKSs) to produce novel bioactive compounds has been a goal for over 20 years. The apparent modularity of PKSs has inspired many engineering attempts in which entire modules or single domains were exchanged. In recent years, it has become evident tha...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Klaus, Maja, D’Souza, Alicia D., Nivina, Aleksandra, Khosla, Chaitan, Grininger, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554747/
https://ncbi.nlm.nih.gov/pubmed/30682239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b01060
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