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Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains

Engineering of assembly line polyketide synthases (PKSs) to produce novel bioactive compounds has been a goal for over 20 years. The apparent modularity of PKSs has inspired many engineering attempts in which entire modules or single domains were exchanged. In recent years, it has become evident tha...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Klaus, Maja, D’Souza, Alicia D., Nivina, Aleksandra, Khosla, Chaitan, Grininger, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554747/
https://ncbi.nlm.nih.gov/pubmed/30682239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b01060
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