Near neighbor interactions in the NS3–4A protease of HCV impact replicative fitness of drug-resistant viral variants

A variety of amino acid substitutions in the NS3–4A protease of the hepatitis C virus (HCV) lead to protease inhibitor (PI) resistance. Many of these significantly impair the replication fitness of the resistant variants in a genotype- and subtype-dependent manner, a critical factor in determining t...

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Pubblicato in:J Mol Biol
Autori principali: Doncheva, Nadezhda T., Domingues, Francisco S., McGivern, David R., Shimakami, Tetsuro, Zeuzem, Stefan, Lengauer, Thomas, Lange, Christian M., Albrecht, Mario, Welsch, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6554042/
https://ncbi.nlm.nih.gov/pubmed/31051172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.04.034
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