Near neighbor interactions in the NS3–4A protease of HCV impact replicative fitness of drug-resistant viral variants

Lignende værker

• Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C-terminal helix α(18)
  af: Stross, Claudia, et al.
  Udgivet: (2016)
• Protease Inhibitor-Resistant Hepatitis C Virus Mutants with Reduced Fitness from Impaired Production of Infectious Virus
  af: Shimakami, Tetsuro, et al.
  Udgivet: (2010)
• Ketoamide Resistance and Hepatitis C Virus Fitness in Val55 Variants of the NS3 Serine Protease
  af: Welsch, Christoph, et al.
  Udgivet: (2012)
• Peptidomimetic Escape Mechanisms Arise via Genetic Diversity in the Ligand-Binding Site of the Hepatitis C Virus NS3/4A Serine Protease
  af: Welsch, Christoph, et al.
  Udgivet: (2011)
• Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors
  af: Dultz, Georg, et al.
  Udgivet: (2020)