Protease Inhibitor-Resistant Hepatitis C Virus Mutants with Reduced Fitness from Impaired Production of Infectious Virus

BACKGROUND & AIMS: Several small molecule inhibitors of the hepatitis C virus (HCV) NS3/4A protease have advanced successfully to clinical trials. However, the selection of drug-resistant mutants is a significant issue with protease inhibitors (PIs). A variety of amino acid substitutions in the...

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Main Authors: Shimakami, Tetsuro, Welsch, Christoph, Yamane, Daisuke, McGivern, David, Yi, MinKyung, Zeuzem, Stefan, Lemon, Stanley M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155954/
https://ncbi.nlm.nih.gov/pubmed/21056040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.10.056
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