Ketoamide Resistance and Hepatitis C Virus Fitness in Val55 Variants of the NS3 Serine Protease

Drug-resistant viral variants are a major issue in the use of direct-acting antiviral agents in chronic hepatitis C. Ketoamides are potent inhibitors of the NS3 protease, with V55A identified as mutation associated with resistance to boceprevir. Underlying molecular mechanisms are only partially und...

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Bibliografiske detaljer
Main Authors: Welsch, Christoph, Schweizer, Sabine, Shimakami, Tetsuro, Domingues, Francisco S., Kim, Seungtaek, Lemon, Stanley M., Antes, Iris
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318394/
https://ncbi.nlm.nih.gov/pubmed/22252823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05184-11
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